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Oncogene - . Gene Amplification-Associated Overexpression of the RNA Editing Enzyme ADAR1 Enhances Human Lung T >>


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Manel Esteller, Josep Baselga and Joan Massagué receive the XXVIII Catalonia International Prize from President Puigdemont

Dr Manel Esteller

The President of the Generalitat de Catalunya (Catalan Government), Carles Puigdemont, awarded oncologists Manel Esteller, Joan Massagué and Josep Baselga the 28th Catalunya International Prize “for his revolutionary task, especially on oncology research, with what they significantly contributed to the advances of global medicine”. These awards are given every year to people who contributed with their work to develop cultural, scientific or human values worldwide. Manel Esteller, who is National Research Award 2015, teaches in the Department of Physiological Sciences of the University of Barcelona. Director of the Cancer Epigenetics and Biology Program of the Bellvitge Biomedical Research Institute (IDIBELL), he is an international prestigious expert on the study of methylation (biochemical DNA modification) as an altering mechanism of the suppressing genes on human tumors, and focuses his research on studying the epigenetic modifications and development of new epigenetic drugs to treat cancer. Esteller was also honoured with the Rey Jaime I Prize on basic research (2013), XX Severo Ochoa Award for Biomedical Research (2013), the Vanguardia Science Award (2014) or the Medal Josep Trueta to health merit (2015) among other awards. During the ceremony, which took place during a solemn ceremony in the Sant Jordi Hall of the Palau de la Generalitat, the three winners expressed their gratitude. Dr. Baselga has referred to the new immunological treatments, which he said "continue revolutionizing cancer therapies." As for Dr. Esteller, he asked that Catalonia "bears research in mind, recognizes research as an outstanding value for a country." And Dr. Massagué mentioned the ten principles on the basis of the science building, which he compared with the casteller world. After congratulating the three winners and thanking them for their task, the president of the Generalitat, Carles Puigdemont, said that the three scientists "represent the values ??and virtues that are needed to become a world reference in a field of study that is, in this case, oncological research. He added that the three "went outside Catalonia to investigate, to train, to discover and understand the world" and have become representatives of values ??such as "imagination, dare, effort, hard work, perseverance, tenacity and courage ". 138 applications from 57 countries The Catalonia International Prize, created by the Government in 1989, is annually awarded to those who have contributed decisively through their creative work to support cultural, scientific or human values ??around the world. Last year, the British anthropologist and primatologist Jane Goodall received the Award. In this edition of the Catalonia International Prize, a total of 138 entries from 57 countries were submitted by 246 institutions and by the same jury.


Catalonia's Parliament awards its medal of honor to Dr. Manel Esteller

Dr Manel Esteller

Catalonia's parliament has given, as part of the celebration of the National Day of Catalonia, the medal of honor in the category of gold to Dr. Manel Esteller, "for his career as a Catalan physician and researcher of international reference". During the ceremony, the president Carmen Forcadell, and the president of the Generalitat, Carles Puigdemont, have highlighted the importance of research in Catalonia and its contribution to the fight against cancer. Esteller has vouched for the talent and training of future generations. Last July, the Parliament's board unanimously agreed to grant the distinction, which recognizes "the research work and achievements" of Dr Esteller "in his fight against human cancer" and "his contribution to the projection of Catalonia as a leading country in scientific research", also highlighting "his contribution to the collective progress the application of his research represented for areas as diverse as human and social sciences, life sciences and health, engineering, technology and experimental sciences." At the beginning of the act, Dr. Jesus Urena, professor at the Faculty of Biology of the University of Barcelona, ??presented Dr. Esteller's biography and main achievements. After that, the president handed the medal to Dr. Esteller, who then pronounced some gratitude words which stressed the importance of research, and the training of future generations, because although "there are still very serious health problems", we must keep investigating. "I will continue investigating, it is what I do and what I like," he said, but "the dream" of a "better health for all" sometimes "depends on other people who will come after." "Please, set today the foundation for a society based on education and knowledge" he asked. The president thanked Esteller for his commitment to "trying to do, from Catalonia, the world a little better." Forcadell stressed that "the fight against cancer" is "one the that belongs to all humanity," adding that "it is a source of pride that our country contributes to this universal task". She said that "institutions will provide all resources" possible to further enhance research and investigation, main areas "of a society that does not resign". "And this country, history shows, is not resigned" she said. Puigdemont stressed that the medal "honors the recipient" but that "we are also honored as a country". "When we ask what kind of people Catalans are, that is how we want to be known in the world"; "we would like to be recognized as a people who are able to make significant contributions to the change and progress of humanity" said the president. "It is no coincidence that in Catalonia there are pioneer researchers working in areas such as AIDS or cancer." The event ended with performances of 'La Sardana de l'Abril', composed by Lluís M. Millet from a poem by Joan Llongueras; 'L'amor mariner', composed by Manuel Oltra from a poem by Pere Quart, and finally, 'Els Segadors', the national anthem of Catalonia, with the audience standing.


Manel Esteller receives the National Research Prize 2015

Dr Manel Esteller

The Government of Catalonia and the Catalan Foundation for Research and Innovation (FCRI) have awarded Manel Esteller the National Research Award 2015. Manel Esteller is an ICREA research professor, director of the Epigenetics and Cancer Biology Program of the Institute of Biomedical Research of Bellvitge since 2008, head of the cancer Epigenetics Group of the center and professor of Genetics at the Department of Physiological Sciences II of the Faculty of Medicine of the University of Barcelona. Manel Esteller has carried out pioneering research and international leadership in epigenetics (the study of heritable changes in gene function derived from external or environmental factors unrelated to DNA sequence) as a key factor in cancer development. His work has been decisive in studying methylation as a mechanism of altering human tumor suppressor genes. Currently, the awarded focuses its research on the development of the epigenomic maps of normal and transformed cells, the study of epigenetic modifications and development of new epigenetic drugs for treating cancer. The National Research Prize recognizes the researcher who has recently contributed, significantly and internationally, to the advancement of a scientific discipline in all its areas: humanities and social sciences, life sciences and health, engineering and technology and experimental sciences. Manel Esteller graduated in Medicine and Surgery at the University of Barcelona, and obtained his doctorate at the same university with a thesis on molecular genetics of endometrial carcinoma. He is the author of more than four hundred articles in the field of medical sciences, member of several scientific societies and critical of numerous international scientific journals. He has also received several awards, including the Rei Jaume I Prize for basic research (2013), the twentieth Severo Ochoa Prize for Biomedical Research (2013), the Vanguardia Award for Science (2014) and, among others, the Josep Trueta Medal for health merit (2015 ).


Eva Gonzalez Suarez gets Consolidator Grant from the European Research Council

Dr Manel Esteller

The head of the group of Transformation and Metastasis PEBC-IDIBELL, Eva Gonzalez Suarez has received an ERC Consolidator Grant from the European Research Council (ERC) to develop its PLEIO-RANK project to develop a single therapy capable of reducing metastasis and mortality in solid tumors. The grant supposes a funding 2 million Euros for the next five years. Thousands of cancer patients worldwide are taking RANKL inhibitors for the management of bone metastases, based on the key role of RANKL and its receptor RANK in osteoclasts. "We have shown" explains the researcher "that overexpression of RANK induces stemness, interferes with differentiation in transformed mammary epithelial cells, and promotes the early stages of mammary tumorigenesis acting as a paracrine mediator of progesterone." "The PLEIO-RANK project" adds, "is intended to explore the therapeutic potential of inhibiting RANK signaling in other solid tumors, not only as a preventive strategy, but also during tumor progression, recurrence and metastases. We will dissect the role of this pathway in tumor cells and in surrounding stroma." Inhibition of RANK could become a single therapy aimed at reducing mortality and metastasis in solid tumors by its pleiotropic antitumor effects on cancer and stromal cells. The Consolidator Grants aim to promote the career of talented researchers with an innovative vision who have demonstrated their research potential and scientific maturity.


Manel Esteller receives Josep Trueta health merit medal

Dr Manel Esteller

The director of the Epigenetics and Cancer Biology, Manel Esteller received the medal Josep Trueta to the sanitary merit of this year. The ceremony took place on May 12th at the Palau de la Generalitat, headed by Artur Mas, president of the Generalitat, and Boi Ruiz, head of Health Department. Josep Trueta medals and plaques, given annually by the Generalitat of Catalonia, distinguished persons and entities that, on its merits, have highlighted significantly for services rendered in order to progress and improving health. The Josep Trueta medals and plaques were created in 1997, coinciding with the centenary of the birth of renowned Catalan doctor and scientist.



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