The Lancet Oncology - Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis >>


Nature Medicine - Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGF >>


Genome Biology - Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer >>


Oncogene - . Gene Amplification-Associated Overexpression of the RNA Editing Enzyme ADAR1 Enhances Human Lung T >>


Neuropsychopharmacology - Improvement of the Rett syndrome phenotype in a MeCP2 mouse model upon treatment with levodopa and a >>


Molecular Cell - Liz J, Portela A, Soler M, Gmez A, Ling H, Michlewski G, Calin GA, Guil S, Esteller M. >>


Nature Communications - A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect. Lopez-Serra P, M >>



Catalonia's Parliament awards its medal of honor to Dr. Manel Esteller

Dr Manel Esteller

Catalonia's parliament has given, as part of the celebration of the National Day of Catalonia, the medal of honor in the category of gold to Dr. Manel Esteller, "for his career as a Catalan physician and researcher of international reference". During the ceremony, the president Carmen Forcadell, and the president of the Generalitat, Carles Puigdemont, have highlighted the importance of research in Catalonia and its contribution to the fight against cancer. Esteller has vouched for the talent and training of future generations. Last July, the Parliament's board unanimously agreed to grant the distinction, which recognizes "the research work and achievements" of Dr Esteller "in his fight against human cancer" and "his contribution to the projection of Catalonia as a leading country in scientific research", also highlighting "his contribution to the collective progress the application of his research represented for areas as diverse as human and social sciences, life sciences and health, engineering, technology and experimental sciences." At the beginning of the act, Dr. Jesus Urena, professor at the Faculty of Biology of the University of Barcelona, ??presented Dr. Esteller's biography and main achievements. After that, the president handed the medal to Dr. Esteller, who then pronounced some gratitude words which stressed the importance of research, and the training of future generations, because although "there are still very serious health problems", we must keep investigating. "I will continue investigating, it is what I do and what I like," he said, but "the dream" of a "better health for all" sometimes "depends on other people who will come after." "Please, set today the foundation for a society based on education and knowledge" he asked. The president thanked Esteller for his commitment to "trying to do, from Catalonia, the world a little better." Forcadell stressed that "the fight against cancer" is "one the that belongs to all humanity," adding that "it is a source of pride that our country contributes to this universal task". She said that "institutions will provide all resources" possible to further enhance research and investigation, main areas "of a society that does not resign". "And this country, history shows, is not resigned" she said. Puigdemont stressed that the medal "honors the recipient" but that "we are also honored as a country". "When we ask what kind of people Catalans are, that is how we want to be known in the world"; "we would like to be recognized as a people who are able to make significant contributions to the change and progress of humanity" said the president. "It is no coincidence that in Catalonia there are pioneer researchers working in areas such as AIDS or cancer." The event ended with performances of 'La Sardana de l'Abril', composed by Lluís M. Millet from a poem by Joan Llongueras; 'L'amor mariner', composed by Manuel Oltra from a poem by Pere Quart, and finally, 'Els Segadors', the national anthem of Catalonia, with the audience standing.


Manel Esteller receives the National Research Prize 2015

Dr Manel Esteller

The Government of Catalonia and the Catalan Foundation for Research and Innovation (FCRI) have awarded Manel Esteller the National Research Award 2015. Manel Esteller is an ICREA research professor, director of the Epigenetics and Cancer Biology Program of the Institute of Biomedical Research of Bellvitge since 2008, head of the cancer Epigenetics Group of the center and professor of Genetics at the Department of Physiological Sciences II of the Faculty of Medicine of the University of Barcelona. Manel Esteller has carried out pioneering research and international leadership in epigenetics (the study of heritable changes in gene function derived from external or environmental factors unrelated to DNA sequence) as a key factor in cancer development. His work has been decisive in studying methylation as a mechanism of altering human tumor suppressor genes. Currently, the awarded focuses its research on the development of the epigenomic maps of normal and transformed cells, the study of epigenetic modifications and development of new epigenetic drugs for treating cancer. The National Research Prize recognizes the researcher who has recently contributed, significantly and internationally, to the advancement of a scientific discipline in all its areas: humanities and social sciences, life sciences and health, engineering and technology and experimental sciences. Manel Esteller graduated in Medicine and Surgery at the University of Barcelona, and obtained his doctorate at the same university with a thesis on molecular genetics of endometrial carcinoma. He is the author of more than four hundred articles in the field of medical sciences, member of several scientific societies and critical of numerous international scientific journals. He has also received several awards, including the Rei Jaume I Prize for basic research (2013), the twentieth Severo Ochoa Prize for Biomedical Research (2013), the Vanguardia Award for Science (2014) and, among others, the Josep Trueta Medal for health merit (2015 ).


Eva Gonzalez Suarez gets Consolidator Grant from the European Research Council

Dr Manel Esteller

The head of the group of Transformation and Metastasis PEBC-IDIBELL, Eva Gonzalez Suarez has received an ERC Consolidator Grant from the European Research Council (ERC) to develop its PLEIO-RANK project to develop a single therapy capable of reducing metastasis and mortality in solid tumors. The grant supposes a funding 2 million Euros for the next five years. Thousands of cancer patients worldwide are taking RANKL inhibitors for the management of bone metastases, based on the key role of RANKL and its receptor RANK in osteoclasts. "We have shown" explains the researcher "that overexpression of RANK induces stemness, interferes with differentiation in transformed mammary epithelial cells, and promotes the early stages of mammary tumorigenesis acting as a paracrine mediator of progesterone." "The PLEIO-RANK project" adds, "is intended to explore the therapeutic potential of inhibiting RANK signaling in other solid tumors, not only as a preventive strategy, but also during tumor progression, recurrence and metastases. We will dissect the role of this pathway in tumor cells and in surrounding stroma." Inhibition of RANK could become a single therapy aimed at reducing mortality and metastasis in solid tumors by its pleiotropic antitumor effects on cancer and stromal cells. The Consolidator Grants aim to promote the career of talented researchers with an innovative vision who have demonstrated their research potential and scientific maturity.


Manel Esteller receives Josep Trueta health merit medal

Dr Manel Esteller

The director of the Epigenetics and Cancer Biology, Manel Esteller received the medal Josep Trueta to the sanitary merit of this year. The ceremony took place on May 12th at the Palau de la Generalitat, headed by Artur Mas, president of the Generalitat, and Boi Ruiz, head of Health Department. Josep Trueta medals and plaques, given annually by the Generalitat of Catalonia, distinguished persons and entities that, on its merits, have highlighted significantly for services rendered in order to progress and improving health. The Josep Trueta medals and plaques were created in 1997, coinciding with the centenary of the birth of renowned Catalan doctor and scientist.


Help us to investigate new treatments for children affected by Rett Syndrome: our new Crowdfunding Project in Verkami.

Dr Manel Esteller

The Rett Syndrome is the second most common cause of intellectual disability in females after Down Syndrome. It is a neuronal developmental disease whose clinical symptoms begin to appear 6-18 months after birth and is characterized by an intellectual, social and motor skills impairments accompanied by autistic behaviours, such as repeated hand movements. It affects approximately 1 in 10,000 or 15,000 girls and is usually due to the presence of a mutation in the gene MECP2, an epigenetic gene which controls the activity of many other genes of the cell. Today there is no effective treatment for Rett syndrome, but the latest scientific developments indicate that we may be able to reverse the syndrome. To date, we have investigated various compounds that appear to improve some of the effects of the MECP2 mutation but we are still far away to understand that complex disease and to test all possible drugs. Help us to improve the life of girls affected by Rett Syndrome. Your donations of 10 or 25 Euros can make the difference. http://www.verkami.com/projects/9255-investigacion-de-nuevos-tratamientos-para-el-sindrome-de-rett



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